The Biotherapeutics Laboratory brings state-of-the-art discovery capabilities for protein-based drugs to the Moulder Center. Drawing on over 30 years of academic and industrial experience in prokaryotic, eukaryotic and viral molecular genetics, heterologous protein expression and therapeutic antibody discovery and engineering, we utilize phage display technology as our primary protein discovery platform. In mid-2014 we completed a licensing agreement with MorphoSys AG for their “Ylanthia” Fab display phage library, making the Moulder Center the only academic group in the world with access to this powerful industrial-quality human antibody discovery platform. Protein purification is carried out with a GE ÄKTA Explorer FPLC, and rapid clone screening is facilitated by a Hamilton Microlab STARlet liquid handler, BioTek EL406 plate washer/dispenser with magnetic microbead capability, an EnVision multi-label plate reader, and a Luminex MAGPIX fluorescent microbead imager. Protein-protein interaction analysis is carried out by biolayer interferometry using a ForteBio BLItz and by surface plasmon resonance using a Biacore 3000.
For additional information contact:
Jon H. Condra, Ph.D.
Associate Professor, Pharmaceutical Biotechnology
Moulder Center for Drug Discovery Research