The Moulder Center for Drug Discovery Research and School of Pharmacy have eight laboratories with approximately 9,000 square feet and 22 fume hoods dedicated to the synthesis, purification, and study of organic molecules. The chemistry laboratories are designed to handle mg to kg scale small molecule synthesis. Parallel synthesis platforms are also available for the preparation of either diversity driven or focused libraries of 10s to 1000s of compounds on 10 – 100 mg scale. The Moulder center labs and associated facilities are also suitable for large scale synthesis to meet the needs of PK studies, in vivo animal studies, and cGMP production.
In addition to the standard laboratory glassware and equipment (e.g. rotovaps, balances, vacuum pumps, etc.), the Moulder Center labs are equipped with:
- Gilson 215 semi-preparative HPLC system
- Gilson GX-281 preparative HPLC system
- Genevac EZ-2Evaporator
- CEM Explorer microwave
- Teledyne Isco Combiflash Rf system (2)
- Grace Reveleris HPLC chromatography system with ELSD detection
- Walk in fume hood capabilities for large scale chemistry
Specific Analytical Instrumentation and Equipment Includes:
- Nuclear Magnetic Resonance (NMR) Instruments:
- Bruker 400 MHz NMR (School of Pharmacy)
- Bruker 300, 400 MHz (College of Science and Technology
- GE 500 MHz (College of Science and Technology)
- Mass Spectroscopy:
- Agilent HPLC/MS ESI with PDA
- API 4000 LC/MS/MS
- FT-IR Perkin-Elmer Model 1625.
- X-ray Crystallography via the Dept. of Chemistry, U. of Penn.
- Shimadzu UPLC system LC-20AD suitable for HPLC and GPC.
- TA Instruments Q200 modulated differential scanning calorimeter with RCS cooling unit (range 90°C-400°C).
- Malvern ZS Nano particle size analyzer with zeta potential measurement.
For additional information contact:
Wayne Childers, Ph.D.
Associate Director of the Moulder Center for Drug Discovery Research
Associate Professor, Medicinal Chemistry
Benjamin E. Blass, Ph.D.
Assistant Professor of Medicinal Chemistry
Moulder Center for Drug Discovery Research