Selected Publications and Presentations:
- Development of a novel non-radiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreenÃ’ technology, Cassel, J. A.; Blass, B. E.; Reitz, A. B.; Pawlyk, A. C. J. Biomol. Screen. 2010, in press.
- Development of a novel non-radiometric assay for nucleic acid binding to TDP-43 suitable for high-throughput screening using AlphaScreen technology. Pawlyk A.C.; Cassel J.A.; Blass B.E.; Reitz A.B., Society for Neuroscience, San Diego, CA, 2010.
- Selective Kv1.5 blockers: Development of KVI-020/WYE-160020 as a potential treatment for atrial arrhythmia, Blass, B. E.; Fensome, A.; Trybulski, E.; Magolda, R.; Gardell, S.; Liu, K.; Samuel, M.; Feingold, I.; Huselton, C.; Jackson, C.; Djandjighian, L.; Ho, D.; Hennan, J.; Janusz, J. J. Med. Chem. 2009, 52, 21, 6531-6534.
- Selective Kv1.5 blockers: Development of KVI-020 as a potential treatment for atrial arrhythmia, Blass, B. E.; Coghlan, R.; Fensome, A.; Steffan, R.; Trybulski, E.; Vera, M.; Vu, A.; Webb, M.; Cross, J; Unwalla,R.; Hennan, J.; Liu, K.; Samuel, M.; Eta, J.; Feingold, I.; Huselton, C.; Kao, J.; Tio, C.; Vlasuk, G.; Morgan, G.; Swillo, R.; Rossman, E. I.; Janusz, J. M.; Jackson, C. M.; Djandjighian, L.; Hedges, R. 238th American Chemical Society National Meeting, Aug. 16-20, 2009.
- Kv1.5 inhibitor, WYE-160020, reduces atrial fibrillation/flutter inducibility in post-operative sterile pericarditis and simultaneous atrial/ventricular tachypacing canine models, Rossman, E.I.; Morgan, G.A.; Swillo, R.E.; Liu, K.; Blass, B. E.; Jackson, C. M.; Janusz, J. M.; Fensome, A.; Trybulski, E. J.; Gardell, S. J.; Vlasuk, G. P.; Hennan, J.K., 30th Annual Heart Rhythm Society Meeting, Boston, MA, May 13-16th, 2009.
- 1,4-Dihydro-1-(phenylmethyl)-3-pyridinecarboxamide, Blass, B.E. Encyclopedia of Reagents for Organic Synthesis, 2008.
- Evolution of thiazolidine-based blockers of human Kv1.5 for the treatment of atrial arrhythmias, Jackson, C. M.; Blass, B.; Coburn, K.; Djandjighian, L.; Fadayel, G.; Fluxe, A. J.; Hodson, S. J.; Janusz, J. M.; Murawsky, M.; Ridgeway, J. M.; White, R. E.; Wu, S. Biorg. Med. Chem. Lett. 2007, 17, 1, 282-284.
- Synthesis of 1-aminoimidazolidin-4-one and 1-aminoimidazolidin-2-one based compounds: An interesting divergence in methodology, Blass, B. E.; Coburn, K.; Fairweather, N.; Fluxe, A.; Hodson, S.; Jackson, C.; Janusz, J.; Lee, W.; Ridgeway, J.; White, R.; Wu, S. Tetrahedron Lett. 2006, 47, 42, 7497-7499.
- Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation, Blass, B. E.; Coburn, K.; Lee, W.; Fairweather, N.; Fluxe, A.; Wu, S.; Janusz, J. M.; Murawsky, M.; Fadayel, G.; Fang, B.; Hare, M.; Ridgeway, J.; White, R.; Jackson, C.; Djandjighian, L.; Hedges, R.; Wireko, F. C.; Ritter, A. Biorg. Med. Chem. Lett. 2006, 16, 17, 4629-4632.
- Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 inhibitors, Wu, S.; Blass, B. E.; Coburn, K.; Lee, W.; Fairweather, N.; Fluxe, A.; Janusz, J. M.; Murawsky, M.; Fadayel, G.; Fang, B.; Hare, M.; Ridgeway, J.; White, R.; Jackson, C.; Djandjighian, L.; Hedges, R.; Wireko, F. C.; Ritter, A. Biorg. Med. Chem. Lett. 2006, 16, 24, 6213-6218.
- Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers, Wu, S.; Blass, B. E.; Coburn, K.; Lee, W.; Fairweather, N.; Fluxe, A.; Janusz, J. M.; Murawsky, M.; Fadayel, G.; Fang, B.; Hare, M.; Ridgeway, J.; White, R.; Jackson, C.; Djandjighian, L.; Hedges, R.; Wireko, F. C.; Ritter, A. Biorg. Med. Chem. Lett. 2006, 16, 22, 5859-5863.
- A facile, KF/Al2O3 mediated method for the preparation of functionalized pyrido[2,3-d]pyrimidin-7(8H)-ones, Blass, B. E.; Coburn, K. R.;Fairweather, N.; Sabat, M.; West, L., Tetrahedron Lett. 2006, 47, 18, 3177-3180.
- Solid-phase approach towards the synthesis of functionalized imidazo [1,2-b] pyrazol-2-ones, Blass, B. E.; Srivastava, A.; Coburn, K. R.; Faulkner, A. L.; Janusz, J. J.; Ridgeway, J. M.; Seibel, W. L. Tetrahedron Lett. 2004, 45, 6, 1275-77.
- Solution phase synthesis of imidazo [1,2-b] pyrazol-2-one, an interesting 5,5-fused heterocyclic ring system, Blass, B. E.; Srivastava, A.; Coburn, K. R.; Faulkner, A. L.; Janusz, J. J.; Ridgeway, J. M.; Seibel, W. L. Tetrahedron Lett. 2004, 45, 3, 619-621.
- A simple method for the preparation and selective functionalization of4,5-diaminopyrazoles, Blass, B.E.; Coburn, K. R.; Faulkner, A. L.; Seibel,W. L.; Srivastava, A. Tetrahedron Lett. 2003, 44, 14, 3009-3011.
- Applications of solid supported azide anion: A one-pot, two-step preparation of functionalized 1,2,3-triazoles, Blass, B.E.; Coburn, K. R.: Faulkner, A. L.; Seibel, W. L.; Srivastava, A. Tetrahedron Lett. 2003, 44, 10, 2153-2155.
- KF/Al2O3 mediated organic synthesis, Blass, B.E. Tetrahedron, 2002 58, 46, 9301-9320.
- Solid phase synthesis of funtionalized 1,2,4-triazin-6-ones, Blass, B. E.; Coburn, K. R., Faulkner, A. L.; Liu, S.; Ogden, A.; Portlock, D .E.; Srivastava, A.; Tetrahedron Lett. 2002, 43, 45, 8165-8167.
- Solid phase synthesis of funtionalized 1,2,3-triazoles, Blass, B. E.; Coburn, K. R., Faulkner, A. L.; Hunn, C. L.; Natchus, M. G.; Parker, M.S.; Portlock, D .E.; Tullis, J. S.; Wood, R. Tetrahedron Lett. 2002, 43, 4059-4061.
- A facile, selective KF/ Al2O3 mediated method for the deprotection of aryl silyl ethers and preparation of aryl SEM ethers, Blass, B. E.; Harris, C. L.; Portlock, D. E. Tetrahedron Lett. 2001, 42, 1611-1613.
Selected Patents and Patent Applications:
- Kv1.5 potassium channel inhibitors, Janusz, J. M.; Hodson, S. J.; Bosch G. K.; White R. E.; Blass B. E.; Jackson C. M.; Fairweather, N. T. US Patent 7803827, 2010.
- Preparation of 4-imidazolidinones as Kv1.5 potassium channel inhibitors, Blass, B. E.; Janusz, J. M.; Wu, S.; Ridgeway, J. M.; Coburn, K.; Lee, W.; Fluxe, A. J.; White, R. E.; Jackson, C. M.; Fairweather, N. WO 2009079624, 2009.
- Preparation of 4-imidazolidinones as Kv1.5 potassium channel inhibitors, Blass, B. E.; Janusz, J. M.; Ridgeway, J. M.; Wu, S. WO 2009079630, 2009.
- Kv1.5 potassium channel inhibitors, Janusz, J. M.; Hodson, S. J.; Bosch G. K.; White R. E.; Blass B. E.; Jackson C. M.; Fairweather, N. T. US Patent 7504517, 2009.
- Preparation of 4-oxo-1,3,8-triaza-spiro[4.5]decanes as Kv1.5 potassium channel inhibitors, Janusz, J. M.; Wu, S.; Fairweather, N. T.; Lee, W.; Blass, B. E.; Fluxe, A. J.; Hodson, S. J.; Ridgeway, J. M. WO 2007149873, 2007.
- Imidazolidinone derivatives as Kv1.5 potassium channel inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cardiac arrhythmia, Janusz, J. M.; Hodson, S. J.; Bosch, G. K.; White, R. E.; Blass, B. E.; Jackson, C. M.; Fairweather, N. T. WO 2007149874, 2007.
- Triazole compounds useful in treating diseases associated with unwanted cytokine activity, Tullis, J S.; Van Rens, J. C.; Clark, M. P.; Blass, B. E.; Natchus, M. G.; De, B. US Patent 6787555, 2004.
- Triazole compounds useful in treating diseases associated with unwanted cytokine activity, Tullis, J S.; Van Rens, J. C.; Clark, M. P.; Blass, B. E.; Natchus, M. G.; De, B. US Patent 6727364, 2004.
- Process for making functionalized oxazolidinone compounds, Blass, B. E. US Patent 6635769, 2003.
- N-(1-Phenylethyl)-5-phenyl-imidazole-2-amine compounds, their composition and uses, Blass, B. E.; Liu, S.; Portlock, D. E. US Patent 6596739, 2003.
Invited Lectures:
- Patent Law in the Pharmaceutical Industry, Temple University School of Pharmacy, April 2011.
- Drug Discovery and Development: Modern Methods and Principles, Delaware Valley College, March 2011.
- Modern Methods and Principles of Drug Discovery and Development, Temple University, Department of Biology, March 2011.
- Drug Discovery and Development: Modern Methods and Principles, University of Rochester, March 2011.
- Patent Law in the Pharmaceutical Industry, Drexel College of Medicine, November, 2010.
- Patent Law in the Pharmaceutical Industry, Drexel College of Medicine, 2010.
- Voltage-gated potassium channels as therapeutic targets, Pennsylvania Biotechnology Center, 2010.
- Combinatorial chemistry and the practical chemist’s tool box, Villanova University guest lecturer, 2008.