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Dr. Marlene A Jacobson Publications

Dr. Marlene A JacobsonSelected Publications and Presentations:

  1. Childers, WE, Fan,R., Martinez, R.,  Colussi, DJ,  Melenski, E,  Liu, Y,  Gordon, J, Abou-Gharbia M. and Jacobson, MA.  Novel compounds that reverse the diseased phenotype in Type 2 Gaucher disease patient-derived cells, Bioorg. Med. Chem. Lett., in press.
  2. Jacobson, MA, Jones, LJ, Colussi, DJ and Tanaka, JC , High throughput Ca 2+ flux assay to monitor CNGA3 cyclic nucleotide-gated channel activity and achromatopsia-associated mutant function, (2019) ACS Chem. Neuro., 10:3662-3670.
  3. Brown,RA , Voit,A , Srikanth, M, Thayer, JA, Kingsbury, TJ , Jacobson, MA, Lipinski, MM, Feldman, RA and Awad, O.  mTOR hyperactivity mediates lysosomal dysfunction in Gaucher’s disease iPSC neuronal cells, (2019)  Disease Models and Mechanisms, 12(10): dmm038596 <doi: 10.1242/dmm.038596>.
  4. Martin, DO, Kanuparthi, PS, Holland, SM, Sanders, SS, Einarson, MB, Jacobson, MA and Thomas,   GM.  Identification of novel inhibitors of DLK palmitoylation by high content screening, (2019) Sci. Rep., 9:3632.
  5. Colussi, DJ and Jacobson, MA Patient-derived phenotypic high-throughput assay to identify small molecules restoring lysosomal function in Tay-Sachs disease. (2019) SLAS Discovery 24:295-303.
  6. Jacobson, M, Childers, W and Abou-Gharbia, M, Dopamine Partial Agonists, in Successful Drug Discovery Vol 4, János Fischer, Christian Klein, Wayne E. Childers (Editors),  (2019) Wiley-VCH Verlag GmbH & Co. KGaA


Temple University
Moulder Center for Drug Discovery Research

Temple University School of Pharmacy
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Philadelphia, PA 19140