As an integrated drug discovery facility embedded within Temple University, the Moulder Center for Drug Discovery Research has access to the latest in cutting edge technology and research developed by Temple University faculty and staff. The scientists at the center are actively in engaged in numerous projects that span a wide range of therapeutic areas and involve collaborators from across the globe. Exemplary programs from the rich collection of active research include the following:
- Addiction programs:
GLT-1 enhancers for the treatment of cocaine addiction
D3 modulators for the treatment of psychostimulant abuse
- Neurodegenerative disease programs:
GLT-1 enhancers for the treatment of cerebral palsey
Lysosomal storage disease therapeutics
- Cancer programs:
Selective CDK-9 inhibitors for the treatment of cancer
RAD52 inhibitors for the treatment of cancer
DNA polymerase theta (POLQ) inhibitors for the treatment of cancer
PI3Ka/mTOR inhibitors for the treatment of cancer
Allosteric PARP1 inhibitors for the treatment of cancer
Diagnostic systems for predicting kinase inhibitor resistance response in cancer
- Diabetes programs:
4-HNE scavengers for the prevention of insulin resistance
- Antibiotics programs:
S. aureus RnpA inhibitors as novel antibacterial agents